منابع مشابه
Secretory Component in Human Mammary Carcinoma1
Since secretory component is thought to be a normal glandular epithelial cell product, surgical specimens from patients with mammary carcinoma, an epithelial cancer, were studied with antisera to human free secretory compo nent by indirect immunofluorescence microscopy. Normal breast tissue (10 cases) showed fluorescent epithelial cells confined to normal ducts. This was in marked contrast to i...
متن کاملDemonstration of IgA and secretory component in human hepatocytes.
By the immunoperoxidase technique, immunoglobulin A(IgA) was demonstrated in 50% of human hepatocytes. The positively stained cells showed a tendency towards periportal clustering. Very few plasma cells were identified in the liver. The intrahepatocyte IgA is most probably derived from serum and on its way to the bile ducts. Secretory component (SC) had the same distribution as that of IgA. The...
متن کاملCirculating secretory component in breast neoplasms.
The serum concentrations of IgAp and IgMr associated secretory component (SIgA and SIgM) of 98 patients with neoplasms of the breast were measured. Of the 56 patients with carcinomas, 11 had increased concentrations of circulating SIgM, which was almost twice as sensitive as SIgA as a marker for carcinoma. Concentrations of circulating SIgA and SIgM were independent of expression of secretory c...
متن کاملCleavage of membrane secretory component to soluble secretory component occurs on the cell surface of rat hepatocyte monolayers
Rat liver secretory component is synthesized as an integral membrane protein (mSC) and cleaved to an 80-kD soluble form (fSC) sometime during transcellular transport from the sinusoidal to the bile canalicular plasma membrane domain of hepatocytes. We have used 24-h monolayer cultures of rat hepatocytes to characterize the conversion of mSC to fSC. Cleavage of mSC in cultured hepatocytes is inh...
متن کاملSecretory component production by human bronchial epithelial cells is upregulated by interferon gamma.
Secretory immunoglobulin A (S-IgA) participates in the first noninflammatory line of defence of the respiratory tract. S-IgA consists of dimeric IgA (dIgA) produced by plasma cells and secretory component (SC) produced by epithelial cells. This study compared SC production by primary cultures of human bronchial epithelial cells (HBEC) and by respiratory epithelial cell lines. Among the cell lin...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)79777-2